Datum objave: 20.07.2018. 17:30

Poziv za dostavljanje aplikacija u okviru programa Horizon 2020 za integrisane istraživačke platforme koje omogućavaju razvoj lijekova za pacijente

TOPIC : Integrated research platforms enabling patient-centric drug development

Topic identifier:IMI2-2018-15-01

Publication date:18 July 2018

Types of action: IMI2-RIA Research and Innovation action

DeadlineModel: two-stage

Opening date: 18 July 2018

Deadline: 24 October 2018 17:00:00

2nd stage Deadline: 15 May 2019 17:00:00

Time Zone : (Brussels time)

Topic Description

Specific Challenge:

Despite good progress in many areas of healthcare, it seems that clinical development rather than discovery research is the limiting factor for innovative new products and treatment options to reach patients.

Root causes of this include (i) siloed and competitive development process focussed on single compounds with transient clinical trial infrastructures, (ii) insufficient collaboration among industry and between industry, not-for-profit product developers and academia, (iii) limited patient-centric alignment of stakeholders, and, (iv) in general, the limited focus on individual patient-tailored treatments.

As a result of these, there is a clear shortage of (i) investigators & investigational sites for phase 2-3 clinical trials, (ii) patients for enrolment in such trials, (iii) sharing of insights and use of real-world data, and (iv) investigations of combination treatments, in particular from different sponsors.

Scope:

The action aims to address these issues by creating, in a collaborative rather than competitive manner, a reusable and modular approach for the design and execution of patient-centric platform trials.

It will create best practices, tools and guidelines for establishing multi-company platform trials by leveraging, extending and improving concepts from previous pioneering multi-company platform trials to new disease areas.

The proposal is divided into (i) a set of common foundational elements applicable to all disease areas, (ii) clinical networks and networks of patient-level data and (iii) disease-specific integrated research platforms in several disease areas: major depressive disorder (MDD), tuberculosis (TB), non-alcoholic steatohepatitis (NASH) and neurofibromatosis (NF).

Expected Impact:

Developing the proposed reusable IRP and platform trial approach in Europe will deliver a tangible advantage for developing innovative new medicines, and for advancing fundamental and applied medicines research in general, in academia and industry. This includes four platform trial protocols fully ready for execution for diseases of high unmet need in scope of the World Health Organisation (WHO) priority medicines list.

This will allow patients to benefit quicker from medical innovations, both through accelerating new medicines development in general but also through faster enrolment in clinical trials with a lower chance of being randomised to the placebo, and potentially a higher likelihood of being allocated to the most promising treatments for individual patients, including multi-company combinations of medicines.

It will also increase participation of patients in the design of clinical trials and in the development of predictive biomarkers and trial endpoints that are clinically meaningful and approved by regulators.

Topic conditions and documents

Please read carefully all provisions stated below before the preparation of your application.

The IMI2 JU 15th Call for proposals topics text as well as the Call Conditions are available here.  

The budget breakdown for this Call is given at the end of the Call topics text, in the Call Conditions section, as well as the following information : 

1.   Eligible countries: described in article 10(2) of the Rules for participation in Horizon 2020 and in article 1 of the Commission Delegated Regulation related to IMI JU.

2.   Eligibility and admissibility conditions: described in the IMI2 Manual for evaluation, submission and grant award. See also the Commission Delegated Regulation related to IMI JU.

Proposal page limits and layout: Please refer to Part B of the proposal template in the submission tool below.

3.   Evaluation:
Submission and evaluation process, including evaluation criteria and procedure, scoring and threshold are described in the IMI2 Manual for submission, evaluation and grant award. See also the proposal templates for your specific action in section 5, below.

4.   Indicative time for evaluation and grant agreement:
Notification of outcomes of stage 1 evaluations: maximum 5 months from deadline for submitting proposals.
Notification of outcomes of stage 2 evaluations: maximum 5 months from deadline for submitting full proposals.

Signature of grant agreements: maximum 3 months from the date of informing successful applicants.

5.   Proposal templates, evaluation forms and model grant agreements (MGA):

IMI2 Research and Innovation Action (IMI2-RIA) and Innovation Action (IMI2-IA):

Proposal templates are available after entering the submission tool

Standard evaluation form

IMI2 Model Grant Agreement

Clinical trial template – the Clinical Trial template is compulsory at stage 2 only !

6.   Open access must be granted to all scientific publications resulting from Horizon 2020 actions.

Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.

Open access to research data
The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in Annex L of the H2020 main Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.

Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.

Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.

Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs. See the Online Manual.

Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.

The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement. 

Members of consortium are required to conclude a consortium agreement prior to the signature of the grant agreement.

7. Additional documents:

Summary of the most relevant provisions for participating in IMI2 actions

3rd Amended IMI2 Annual Work Plan 2018

IMI2 Regulators Guidance tool for researchers

IMI JU derogation to H2020 Rules for Participation  

Horizon 2020 Rules for Participation 

Horizon 2020 Regulation of Establishment

Horizon 2020 Specific Programme

https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/imi2-2018-15-01.html